| 摘要: |
| 作为一种高效、局域化且高度可控的纳米热源，金纳米棒越来越多的应用于肿瘤的光热治疗之中。为探讨微观尺度下金纳米棒的产热与传热机理，以及颗粒之间耦合作用对体系光热效应的影响。本文运用基于有限元的COMSOL软件，建立了金纳米棒光热耦合的三维模型，分析了排布方式和颗粒间距等因素对纳米棒光学性质和光热响应的影响。研究表明，不同排布方式下近距离耦合颗粒之间的耦合强度随间距的增大呈指数衰减，在一定间距范围内这种衰减行为可以被等离子体尺度方程描述；单体共振波长照射下，颗粒间的聚集影响光热治疗的效果，在颗粒耦合作用范围内，分散性越高，体系加热效果越好。本文研究模型及所得结论可为金纳米棒的产热与传热机理及肿瘤的光热治疗提供参考与指导。 |
| 关键词: 局域表面等离激元共振，光热耦合，光热治疗，有限元 |
| DOI： |
| 投稿时间：2019-12-25修订日期：2019-12-25 |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| Analysis of the coupling effect of photothermal treatment on plasmon at nanometer scale |
|
wangke, limengya, wangyongqing, liuzunchao, chuzhanpeng
|
| (Zhengzhou University) |
| Abstract: |
| As an efficient, localized and highly controllable nanometer heat source, Au nanorods are increasingly applied in photothermal therapy of tumors. To investigate the mechanism of heat generation and heat transfer of Au nanorods at micro scale and the effect of particle coupling on photothermal effect. In this paper, COMSOL software based on finite element was used to establish a three-dimensional model of photothermal coupling of Au nanorods. The influences of arrangement and particle spacing on the optical properties and photothermal response of the nanorods are analyazed by numerical simulation. The results show that the coupling strength between the particles decreases exponentially with the increase of the distance, which can be described by the plasma scale equation within a certain distance. Under the exposure of the resonance wavelength of the monomer, the aggregation of particles affects the effect of photothermal therapy. Within the scope of particle coupling, the higher the dispersion, the better the heating effect of the system. This study model and conclusions can provide reference and guidance for the mechanism of heat production of gold nanorods and the photothermal treatment of tumors. |
| Key words: localized surface plasmon resonance, photothermal coupling, photothermal therapy, finite element method |